Our Team

Dr. Nathan Boase

Lecturer (QUT)

QUT Contact Details

Brief Curriculum Vitae
since 10/17 Lecturer at the Queensland University of Technology
09/15 – 10/17 Associate Lecturer under the supervision of A/Prof. Kathryn Fairfull-Smith at the Queensland University of Technology, Brisbane, Australia. Working in collaboration with the Free Radical Group and the Soft Matter Materials Group
10/14 – 09/15 Preclinical Imaging Facility Officer at the Translational Research Institute, Brisbane, Australia
05/11 – 11/14 PhD under supervision of A/Prof. Kristofer Thurecht and A/Prof Idriss Blakey, at the Australian Institute for Bioengineering and Nanotechnology and the Centre for Advanced Imaging, University of Queensland, Brisbane Australia.Thesis title: Hyperbranched Polymers for In Vivo Multimodal Molecular Imaging
11/10 – 05/11 Research associate, A/Prof. Kristofer Thurecht and A/Prof Idriss Blakey, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Australia
08/04 – 11/10 Bachelor of Science (Honours), Chemistry major, University of Queensland, Brisbane Australia

Advanced Synthetic Tools
  • Polymer Ligation Methods, including photochemical
  • Efficient post-polymerisation modification
  • RAFT Agent Design, RAFT Polymer Design
  • Nitroxides and alkoxyamines for polymer synthesis
  • Photochemistry initiated by non-electrochemical sources
Hybrid Materials
  • Polymer theranostics and nanomedicines
  • Antibiofilm and antimicrobial polymers
  • Neutral radical polymers with pendant nitroxides side chains – imaging and redox agents
  • Macromolecular Responsive Nano-Containers
  • Macromolecules for enhancing radiotherapy and improving dosimetry
Kinetics and Mechanisms
  • Advanced Photochemical Reaction Systems
  • Controlled Radical Polymerization
  • Polymer Stability Assays
  • Complex Polymer Architecture Formation Processes
Polymer Characterization
  • High resolution NMR analysis of polymeric materials
  • EPR/ESR of stable radical molecules and materials
  • X-Ray Photoelectron Spectroscopy (XPS)
  • Size Exclusion Chromatography with Multiple Detectors
  • Time of Flight – Secondary Ion Mass Spectrometry (ToF-SIMS)
  • Preclinical evaluation of nanomaterials for clinical applications

2019 CAS Future Leader Program. One of 29 ECR Chemists selected worldwide to participate in leadership program run by Chemical Abstract Services from American Chemical Society.
2019 Best Oral Presentation, Eurobiofilms Conference, Glasgow, UK
2018 QUT Science and Engineering Faculty Innovation Award, For innovation and industry collaboration in teaching
2017 QUT Vice Chancellor’s Performance Award, Best Learning Experiences
2014 Best Oral Presentation by an Early Career Researcher, BioNano Conference, Brisbane, Australia
[13] Boase, N. R. B., Nitroxide releasing polymers to protect against bacterial biofilms, 37thAustralasian Polymer Symposium, November 2019, Sunshine Coast, Australia (Invited)
[12] Boase, N. R. B., Designing the properties of soft matter materials for therapies: from dosimetry to theranostics, Brisbane Soft Matter Materials Symposium, November 2019, Brisbane, Australia. (Invited)
[11] Boase, N. R. B., “Getting students to speak our language: adoptive tools for teaching nomenclature”,MACRO – World Polymer Congress, July 2018, Cairns, Aust (Invited)
[10] Boase, N. R. B., Blakey, I., Thurecht, K. J., “Polymeric Theranostics and In Vivo Multimodal Imaging”, 6th Asian Federation of Laboratory Animal Science Associations Congress, November 2014, Kuala Lumpur, Malaysia. (Invited)
[09] Vincent-Ruz, P., Blinco, J., Boase, N., Getting students to speak our language: adaptive tools for teaching nomenclature. 2020 Biennial Conference on Chemical Education. Abstract accepted March 31, 2020. Because of the global COVID-19 pandemic, the 2020 Biennial Conference on Chemical Education was terminated on April 2, 2020, by the Executive Committee of the Division of Chemical Education, American Chemical Society; and, therefore, this presentation could not be given as intended.
[08] Boase N., Torres, D. T., Fletcher, N., de la Fuente-Nunez, C., Fairfull-Smith, K., “Spin Doctor – Synthesis of nitroxide polymers to prevent biofilm fouling”, 6th European Congress on BiofilmsSept 2019, Glasgow, UK.
[07] Blinco, J., Mullen, K., Boase, N., “Getting students to speak our language: Adaptive tools for teaching nomenclature.”, American Chemical Society Congress, March 2018, New Orleans, United States of America.
[06] Boase, N., De La Fuente-Nunez, C., Lang, C., Hancock, R., Fairfull-Smith, K., “Polynitroxides to protect against bacterial biofilms”, American Chemical Society Congress, March 2018, New Orleans, United States of America.
[05] Boase, N. R. B., C., Lang, C., Hancock., R. E. W., Totsika, M., Farifull-Smith, K. E., “Nitroxide releasing polymers to protect against bacterial biofilms”, RACI Centenary CongressJuly 2017, Melbourne, Australia.
[04] Boase, N. R. B., de la Fuente-Núñez, C., Lang, C., Hancock, R. E. W., Fairfull-Smith, K.E., “Polymethacrylate copolymer films containing pendant nitroxides to protect against biofilm formation”, Australian Polymer Symposium, November 2016, Lorne, Australia.
[03] Boase, N. R. B., “Cerego-an adaptive tool for teaching first year students chemistry. AKA: Students don’t like textbooks”, Australian Conference on Science and Mathematics Education, September 2016, Brisbane, Australia.
[02] Boase, N., Blakey, I., Mardon, K. and Thurecht, K., “Development of a Multimodal Hyperbranched Polymer Imaging Agent”, 5th International NanoBio Conference and 3rd International Conference on BioNano Innovation, July 2014, Brisbane, Australia.
[01] Boase, N. R., Blakey, I., Mardon, K. and Thurecht, K. J. “Development of a Multimodal Hyperbranched Polymer Imaging Agent for PET, 19F MRI and Optical Imaging”, World Molecular Imaging Congress, September 2013, Savannah, USA.

2020
[73] Structural elucidation of hydroxy fatty acids by photodissociation mass spectrometry with photolabile derivatives

Narreddula, V. R., Sadowski, P., Boase, N. R. B., Marshall, D. L., Poad, B. L. J., Trevitt, A. J., Mitchell, T. W., Blanksby, S. J. Rapid Communications in Mass Spectrometry, 2020, 34, e8741.

[72] Shining a Light on Bioorthogonal Photochemistry for Polymer Science

Boase., N. R. B. Macromolecular Rapid Communications, 2020, 2000305, ASAP.

2019
[75] Introduction of a fixed-charge, photolabile derivative for enhanced structural elucidation of fatty acids

Narreddula, V. R., Boase, N. R. B., Ailuri, A., Marshall, D. L., Poad, B. L. J., Kelso, M. J., Trevitt, A. J., Mitchell, T. W., Blanksby, S. J. Analytical Chemistry, 2019, 91, 9901-9909.

[74] A very low diffusion Fricke gel dosimeter with functionalised xylenol orange-PVA (XOPVA)

Smith, S. T., Boase, N. R. B., Masters, K-S., Hosokawa, K., Asena A., Crowe, S. B., Kairn, T., Trapp, J. V. Physics in Medicine and Biology, 2019, 64, 205017.

[604] Adaptable and Reprogrammable Surfaces

Goldmann, A. S.; Boase, N. R. B.; Michalek, L.; Blinco, J. P.; Welle, A.; Barner-Kowollik, C. Adv. Mater. 2019, 31, 1902665.

2018
[78] Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids

Hancock, S. E.; Ailuri, R.; Marshall, D. L.; Brown, S. H. J.; Saville, J. T.; Narreddula, V. R.; Boase, N. R. B.; Poad, B. L. J.; Trevitt, A.J.; Willcox, M. D. P.; Kelso, M. J.; Mitchell, T. W.; Blanksby, S. J. J. Lipid Res. 2018, doi:10.1194/jlr.M086702.

[] Xylenol orange functionalised polymers to overcome diffusion in Fricke gel radiation dosimeters

Boase, N. R. B., Smith, S. T.; Masters, K.-S.; Hosokawa, K.; Crowe, S. B.; Trapp, J. V. React. Funct. Polym. 2018, 132, 81-88, doi:10.1016/j.reactfunctpolym.2018.09.011.

[76] Polynitroxide copolymers to reduce biofilm fouling on surfaces

Boase, N. R. B.; Torres, M. D. T.; Fletcher, N. L.; de la Fuente-Nunez, C.; Fairfull-Smith, K. E. Polym. Chem. 2018, 9, 5308-5318, doi:10.1039/C8PY01101J.

2017
[79] In Vivo Fate of Carbon Nanotubes with Different Physicochemical Properties for Gene Delivery Applications

Cifuentes-Rius, A., Boase, N. R. B., Font, I., Coronas, N., Ramos-Perez, V., Thurecht, K. J.; Borrós S. ACS Appl. Mater. Interf. 2017, 9, 11461-11471, DOI: 10.1021/acsami.7b00677.

2016
[81] Synthesis of 19F nucleic acid-polymer conjugates as real-time MRI probes of biorecognition

Sicilia, G., Davis, A. L., Spain, S. G., Magnusson, J. P., Boase, N. R.B., Thurecht, K. J., Alexander, C. Polym. Chem. 2016, 7, 2180-2191, DOI: 10.1039/C5PY01883H.

[80] Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies

Howard, C. B., Fletcher, N., Houston, Z. H., Fuchs, A. V., Boase, N. R. B., Simpson, J. D., Raftery, L. J., Ruder, T., Jones, M. L., de Bakker, C. J., Mahler, S. M., and Thurecht, K. J. Adv. Healthc. Mater. 2016, 5, 2055-2068, DOI: 10.1002/adhm.201600263.

2015
[83] In vivo evaluation of folate decorated cross-linked micelles for the delivery of platinum anticancer drugs

Eliezar, J., Scarano, W., Boase, N. R. B., Thurecht, K. J., and Stenzel, M. H. Biomacromolecules 2015, 16, 515-523, DOI: 10.1021/bm501558d.

[82] The in vivo fate of nanoparticles and nanoparticle-loaded microcapsules after oral administration in mice: Evaluation of their potential for colon-specific delivery

Ma, Y., Fuchs, A. V., Boase, N. R. B., Rolfe, B. E., Coombes, A. G. A, Thurecht, K. J. Eur. J. Pharm. Biopharm. 2015, 94, 393-403, DOI: 10.1016/j.ejpb.2015.06.014

2014
[86] Multimodal Polymer Nanoparticles with Combined F-19 Magnetic Resonance and Optical Detection for Tunable, Targeted, Multimodal Imaging in Vivo

Rolfe, B. E., Blakey, I., Squires, O., Peng, H., Boase, N. R. B., Alexander, C., Parsons, P. G., Boyle, G. M., Whittaker, A. K. and Thurecht, K. J. J. Am. Chem. Soc. 2014, 136, 2413-2419, DOI: 10.1021/ja410351h.

[85] Imaging tumour distribution of a polymeric drug delivery platform in vivo by PET-MRI

Puttick, S., Boase, N. R. B., Blakey, I., Thurecht, K. J. J. Chem. Techn. Biotechnol. 2014, 90, 1237-1244, DOI: 10.1002/jctb.4489, (Joint first author with S. Puttick)

[84] Synthesis of a multimodal molecular imaging probe based on a hyperbranched polymer architecture

Boase, N. R. B., Blakey, I., Rolfe, B. E., Mardon, K. and Thurecht, K. J. Polym. Chem. 2014, 5, 4450-4458, 10.1039/C4PY00513.

2013
[87] Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo

Coles, D. J., Rolfe, B. E., Boase, N. R. B., Veedu, R. N. and Thurecht, K. J. Chem. Commun. 2013, 49, 3836-3838, DOI: 10.1039/C3CC00127J.

2012
[88] Molecular Imaging with Polymers

Boase, N. R. B., Blakey, I. and Thurecht, K. J. Polym. Chem. 2012, 3, 1384-1389, DOI: 10.1039/C2PY20132A.

Tweets

Thank you so much for having me - an absolute pleasure to present @QUTmaterials @QUT

Cool work Philipp! Thank you to all group members for their excellent presentations today @QUT @QUTmaterials @RACIQld

Our very own Bryan Tuten @DrBryanTuten gives the closing plenary at today’s QACS @RACIQld @QUTmaterials @QUT Cool chemistry, Bryan! Thanks to @RACIQld for a great event!