Our Team

A/Prof. Hendrik Frisch

Head of the Soft Matter Materials Laboratory, Associate Professor, DECRA Fellow

QUT Contact Details

Brief Curriculum Vitae
since 08/23
Associate Professor
since 2020 ARC DECRA Fellow
09/16 – 12/19 Postdoctoral researcher under supervision of Prof. Barner-Kowollik, Karlsruhe Institute of Technology (KIT), Germany and Queensland University of Technology (QUT), Australia
05/16 – 08/16 Postdoctoral researcher under supervision of Prof. Pol Besenius, JGU Mainz, Germany
11/12 – 04/16 PhD in Organic Chemistry under supervision of Prof. Pol Besenius, WWU Münster and JGU Mainz, Germany
10/10 – 10/12 Master of Science in Chemistry, WWU Münster, Germany
09/11 – 12/11 Research project in the group of Prof. Peter C. Ford, University of California Santa Barbara, USA
10/07 – 10/10 Bachelor of Science in Chemistry, WWU Münster

Advanced Synthetic Tools
  • Radical Ring-Opening Polymerization
  • Complex Folding Processes of Polymers into Biomimetic Structures
  • Solid and Liquid Phase Peptide Synthesis
  • Peptide-Based Monomer Design
  • Advanced Light-Induced Reactions, λ-Orthogonal Photoswitches and Photochemistry for Macromolecular Design Radical
  • Wavelength Resolved Photochemistry and Action Plots
  • RAFT Agent Design, RAFT Polymer Design
  • Efficient Bonding/Debonding Polymer Systems, Understanding Dynamic Bonding in Polymer Systems, Photochemical Reversible Bonding Systems
Hybrid Materials
  • Peptide-Polymer Hybrid Materials
  • Light Responsive Polymer Materials
  • Biomimetic Synthetic Molecules, Dynamic Photoresponsive Single Chain Nanoparticles (Towards Synthetic Proteins/Biomimetic Adhesives), Precision Single Chain Nanoparticles for Catalysis
  • Macromolecular Responsive Nano-Containers
Kinetics and Mechanisms
  • Intra- and Intermolecular Self-Assembly Processes
  • Supramolecular Polymerization Kinetics
  • Controlled Radical Polymerization
  • Complex Polymer Architecture Formation Processes
Polymer Characterization
  • High Resolution Mass Spectrometry (ESI-MS, MALDI-TOF) of Synthetic Polymers; Hyphenated Techniques (HPLC/LACCC-ESI, SEC-ESI)
  • Size Exclusion Chromatography with Multiple Detectors
  • Small Angle X-Ray Scattering (SAXS)
  • Circular Dichroism (CD) Spectroscopy

since 2020 ARC Discovery Early Career Researcher Award (DECRA)
since 2019 Merck 350th Anniversary Grant
2017-2019 Fellowship of the German National Academy of Science, Leopoldina
2015 DAAD travel grant for the ‘11th International Conference on Advanced Polymers via Macromolecular Engineering’, Yokohoma, Japan
2014 RSC Chemical Science Poster Prize, ‘Challenges in Nanoscience (ISACS15)’, San Diego, USA
2014 DAAD travel grant for the ‘Challenges in Nanoscience (ISACS15)’, San Diego, USA
2012-2014 PhD Fellowship from the ‘Fonds der Chemischen Industrie’ (FCI)
[14] Remote control of macromolecules with different colors of light: from single chains to materials

H. Frisch, Christopher Barner-Kowollik, 37th Australasian Polymer Symposium, Sunshine Coast, Australia. 10-13/11/2019.

[13] Synthesis of macromolecular architectures with different colors of visible light

H. Frisch, Christopher Barner-Kowollik European Polymer Congress EPF 2019, Hersonissos, Greece. 9-14/06/2019.

[12] Controlling Chemical Reactivity with Different Colors of Light – the Next Frontier in Photochemical Macromolecular Synthesis

H. Frisch, Christopher Barner-Kowollik, 12th SPSJ International Polymer Conference, Hiroshima, Japan. 4-7/12/2018. (Invited)

[11] Creating Macromolecular Architectures with Different Colours of Light

H. Frisch, Christopher Barner-Kowollik, Recent Advances in Macromolecular Chemistry, Nagoya, Japan. 3/12/2018. (Invited)

[10] Visible Light Controlled Macromolecular Architectures

H. Frisch, Christopher Barner-Kowollik, 26. Lecture Conference on Photochemistry, Munich, Germany. 10-12/9/2018

[09] Visible light-gated control of macromolecular architectures

H. Frisch, Christopher Barner-Kowollik, MACRO18 World Polymer Congress, Cairns, Australia. 1-5/7/2018

[08] Reprogramming Chemical Bonds with Different Colours of Light

H. Frisch, Christopher Barner-Kowollik, International Symposium of Photopolymer Science, Wuxi, China. 23-25/4/2018. (Invited)

[07] pH-Control of Supramolecular Polymerizations in Water

H. Frisch, P. Besenius. IUPAC 11th International Conference on Advanced Polymers via Macromolecular Engineering (APME 2015), Yokohama, Japan. 18-22/10/2015.

[06] Controlling Supramolecular Polymerizations in Water

H. Frisch, P. Besenius. 5th Training School on Supramolecular Chemistry in Water, Padova, Italy. 11-14/11/2014.

[05] pH Responsive Supramolecular Polymerizations

H. Frisch, P. Besenius. POLY Symposium “Responsive Nanostructures and Nanocomposites”, 247th ACS National Meeting, Dallas, US. 16-20/3/2014.

[04] pH-Gesteuerte supramolekulare Polymerisationen in Wasser

H. Frisch, P. Besenius. Regionales Stipendiatentreffen des Fonds der Chemischen Industrie (FCI), Münster, Germany. 12/12/2013.

[03] pH Controlled Supramolecular Polymerization

H. Frisch, P. Besenius. Ghent-Münster Mini-Symposium in Supramolecular and Polymer Chemistry, CeNTech,
Münster, Germany. 10/10/2013.

[02] Controlling Supramolecular Copolymerisation via pH

H. Frisch, P. Besenius. IUPAC 10th International Conference on Advanced Polymers via Macromolecular Engineering (APME), Durham, UK. 18-22/8/2013.

[01] Responsive Supramolecular Copolymers

H. Frisch, P. Besenius. 2nd German Symposium in Supramolecular Chemistry, Münster, Germany. 14-15/2/2013.

[764] How Molecular Architecture Defines Quantum Yields

Pashley-Johnson, F.; Munaweera, R.; Houssain, S. I.; Gauci, S.; Delafresnaye, L.; Frisch, H.; O’Mara, M. L.; Du Prez, F. E.; Barner-Kowollik, C. 2024, submitted.

[758] Visible Light Photoflow Synthesis of a Cu(II) Single-Chain Polymer Nanoparticle Catalyst

Gillhuber, S.; Holloway, J. O.; Mundsinger, K.; Kammerer, J. A.; Frisch, H.; Barner-Kowollik, C.; Roesky, P. W. 2024, submitted.

[757] Förster resonance energy transfer within single chain nanoparticles

Maag, P. H.; Feist, F.; Frisch, H.; Roesky, P. W.; Barner-Kowollik, C. Chem. Sci. 2024, 15, 5218-5224.

[756] Photochemical Action Plots Reveal Red-shifted Wavelength-dependent Photoproduct Distributions

Carroll, J. A.; Pashley-Johnson, F.; Frisch, H.; Barner-Kowollik, C. Chem. Eur. J. 2024, 30, e202304174.

[745] Simultaneously Recorded Photochemical Action Plots Reveal Orthogonal Reactivity

Irshadeen, I. M.; Truong, V. X.; Frisch, H.; Barner-Kowollik, C. Chem. Commun. 2023, 59, 11959-11962.

[738] Visible-Light-Induced Control over Reversible Single-Chain Nanoparticle Folding

Maag, P. H.; Feist, F.; Truong, V. X.; Frisch, H.; Roesky, P. W.; Barner-Kowollik, C. Angew. Chem. Int. Ed. 2023, 62, e202309259.

[736] Ferrocene-driven single-chain polymer Compaction

Gillhuber, S.; Holloway, J. O.; Frisch, H.; Feist, F.; Weigend, F.; Barner-Kowollik, C.; Roesky P. W. Chem. Commun. 2023, 59, 4672-4675.

[04] Programming Photodegradability into Vinylic Polymers via Radical Ring-Opening Polymerization

Do, P. T.; Poad, B. L. J.; Frisch, H. Angew. Chem. Int. Ed. 2023, 62, e202213511.

[734] Two Functions from a Single Photoresist: Tuning Microstructure Degradability from Light-Stabilized Dynamic Materials

Gauci, S. C.; Ehrmann, K.; Gernhardt, M.; Tuten, B.; Blasco, E.; Frisch, H.; Jayalatharachchi, V.; Blinco, J. P.; Houck, H. A.; Barner-Kowollik, C. Adv. Mater. 2023, 35, 2300151.

[712] 3D Printed Microstructures Erasable by Darkness

Gauci, S. C.; Gernhardt, M.; Frisch, H.; Houck, H. A.; Blinco, J. P.; Blasco, E.; Tuten, B. T.; Barner-Kowollik, C. Adv. Funct. Mater. 2023, 33, 2206303. 

[03] Peptide based folding and function of single polymer chains

Kalmer, H.; Sbordone, F.; Frisch, H. Polym. Chem. 2022, 13, 5458-5462.

[02] Trends in Polymer Degradation Across All Scales

Veskova, J.; Sbordone, F.; Frisch, H. Macromol. Chem. Phys. 2022, 223, 2100472.

[725] Red Light Induced Folding of Single Polymer Chains

Irshadeen, I. M.; Truong, V. X.; Frisch, H.; Barner-Kowollik, C. Chem Commun. 2022, 58, 12975-12978.

[723] Fluorescent and Catalytically Active Single Chain Nanoparticles

Maag, P. H.; Feist, F.; Frisch, H.; Roesky, P. W.; Barner-Kowollik, C. Macromolecules 2022, 55, 9918-9924.

[708] Green Light Enabled Staudinger-Bertozzi Ligation

Kalayci, K.; Frisch, H.; Barner-Kowollik, C.; Truong, V. X. Chem Commun. 2022, 58, 6397-6400.

[707] Photostationary State in Dynamic Covalent Networks

Chambers, L. C.; Barner-Kowollik, C.; Barner, L.; Michalek, L.; Frisch, H. ACS Macro Lett. 2022, 11, 532-536.

[705] Orange-Light-Induced Photochemistry Gated by pH and Confined Environments

Kodura, D.; Rodrigues, L. L.; Walden, S. L.; Goldmann, A. S.; Frisch, F.; Barner-Kowollik, C. J. Am. Chem. Soc. 2022, 144, 6343-6348.

[687] Light-Gated Control of Conformational Changes in Polymer Brushes

Bialas, S.; Krappitz, T.; Walden, S. L.; Kalayci, K.; Kodura, D.; Frisch, H.; MacLeod, J. M.; Nelson, A.; Michalek, L.; Barner-Kowollik, C. Adv. Mater. Technol. (Special Issue), 2022, 7, 2100347.

[697] Action Plots in Action: In-Depth Insights into Photochemical Reactivity

Irshadeen, I. M.; Walden, S. L.; Wegener, M.; Truong, V. X.; Frisch, H.; Blinco, J. P.; Barner-Kowollik, C. J. Am. Chem. Soc. 2021, 143, 21113-21126. 

[689] Green Light LED Activated Ligation of a Scalable, Versatile Chalcone Chromophore

Irshadeen, I. M.; de Bruycker, K.; Micallef, A. S.; Walden, S. L.; Frisch, H.; Barner-Kowollik, C. Polym. Chem. 2021, 12, 4903-4909. 

[685] Wavelength-Selective Softening of Hydrogel Networks

Pelloth, J. L.; Tran, P. A.; Walther, A.; Goldmann, A. S.; Frisch, H.; Truong, V. X.; Barner-Kowollik, C. Adv. Mater. 2021, 33, 2102184. 

[674] Modular Functionalization and Hydrogel Formation via Red-shifted and Self-reporting [2+2] Cycloadditions

Ludwanowski, S.; Hoenders, D.; Kalayci, K.; Frisch, H.; Barner-Kowollik, C.; Walther, A. Chem. Commun. 2021, 57, 805-808.

[648] Computational Prediction of the Molecular Configuration of Three-Dimensional Network Polymers

De Keer, L.; Kilic, K. I.; Van Steenberge, P. H. M.; Daelemans, L.; Kodura, D.; Frisch, H.; De Clerck, K.; Reyniers, M. F.; Barner-Kowollik, C.; Dauskardt, R. H.; D’hooge, D. R. Nat. Mater. 2021, 20, 1422-1430. (see journal cover)

[636] Light-Fueled Dynamic Covalent Crosslinking of Single Polymer Chains in Non-Equilibrium States

Kodura, D.; Houck, H. A.; Bloesser, F. R.; Goldmann, A. S.; Du Prez, F. E.; Frisch, H.; Barner-Kowollik, C. Chem. Sci. 2021, 12, 1302-1310. 

[01] Photocycloreversions within single polymer chains

Liu, M.; Wenzel, W.; Frisch, H. Polym. Chem. 2020, 11, 6616-6623.

[656] A Holistic Approach for Anthracene Photochemistry Kinetics

Kislyak, A.; Kodura. D.; Frisch, H.; Feist, F.; Van Steenberge, P. H. M.; Barner-Kowollik, C.; D’hooge, D. R Chem. Eng. J. 2020, 402, 126259.

[653] Green Light Triggered [2+2] Cycloaddition of Halochromic Styrylquinoxaline – Controlling Photoreactivity by pH

Kalayci, K.; Frisch, H.; Truong, V. X.; Barner-Kowollik, C. Nat. Commun. 2020, 11, 4193.

[651] Photocycloadditions in Disparate Chemical Environments

Marschner D. E; Kamm, P. W.; Frisch, H.; Unterreiner, A.-N.; Barner-Kowollik, C. Chem. Commun. 2020, 56, 14043-14046.

[649] Multi-material 3D Microstructures with Photochemically Adaptive Mechanical Properties

Gernhardt, M.; Frisch, H.; Welle, A.; Jones, R.; Wegener, M.; Blasco, E.; Barner-Kowollik, C. J. Mater. Chem C 2020, 8, 10993-11000.

[644] 2D Fabrication of Tuneable Responsive Interpenetrating Polymer Networks from a Single Photoresist

Michalek, L.; Bialas, S.; Walden, S.; Bloesser, F. R.; Frisch, H.; Barner-Kowollik, C. Adv. Funct. Mater. 2020, 30, 2005328.

[630] Tacticity Dependence of Single Chain Polymer Folding

Danilov, D.; Sedghamiz, E.; Fliegl, H.; Frisch, H.; Barner-Kowollik, C.; Wenzel, W. Polym. Chem. 2020, 11, 3439-3445.

[627] Macromolecular Superstructures: A Future Beyond Single Chain Nanoparticles

Frisch, H.; Tuten, B. T.; Barner-Kowollik, C. Isr. J. Chem. 2020, 60, 86-99. (invited contribution to Rosarium Philosophorum)

[624] Wavelength-Dependent Stiffening of Hydrogel Matrices via Redshifted [2+2] Photocycloadditions

Kalayci, K.; Frisch, H.; Barner-Kowollik, C., Truong, V. X. Adv. Funct. Mater. 2020, 30, 1908171.

[622] Wavelength-Gated Photoreversible Polymerization and Topology Control

Frisch, H.; Mundsinger, K.; Poad, B. L. J.; Blanksby, S. J.; Barner-Kowollik, C. Chem. Sci. 2020, 11, 2834-2842.

[614] Wavelength-Selective Folding of Single Polymer Chains with Different Colors of Visible Light

Frisch, H.; Kodura, D.; Bloesser, F. R.; Michalek, L.; Barner-Kowollik, C. Macromol. Rapid Commun. 2020, 41, 1900414. (Special Issue dedicated to 100 Years of Macromolecular Chemistry) (see journal cover)

[04] Revealing the Wavelength Dependence of Photochemical Reactions: Cutting-Edge Research in the Teaching Lab

Walden, S.; Frisch, H.; Unterreiner, B.; Unterreiner, A.-N.; Barner-Kowollik, C. J. Chem. Educ. 2020, 97, 543-548.

[610] Time-Dependent Differential and Integral Quantum Yields for Wavelength-Dependent [4+4] Photocycloadditions

Kislyak, A.; Frisch, H.; Gernhardt, M.; Van Steenberge, P. H. M.; D’hooge, D. R.; Barner-Kowollik, C. Chem. Eur. J. 2020, 26, 478-484.

[564] Synthesis of Single-Ring Nanoparticles Mimicking Natural Cyclotides by a Stepwise Folding-Activation-Collapse Process

Rubio-Cervilla, J.; Frisch, H.; Barner-Kowollik, C.; Pomposo, J. Macromol. Rapid Commun. 2019, 40, 1800491. (special issue 40 years MRC)

[569] Contemporary Photoligation Chemistry: The Visible Light Challenge

Offenloch, J. T.; Gernhardt, M.; Blinco, J. P.; Frisch, H.; Mutlu, H.; Barner-Kowollik, C. Chem. Eur. J. 2019, 25, 3700-3709.

[583] Controlling Chain Coupling and Single-Chain Ligation by Two Colours of Visible Light

Frisch, H.; Bloesser, F. R.; Barner-Kowollik, C. Angew. Chem. Int. Ed. 2019, 58, 3604-3609.

[587] Access to Disparate Soft Matter Materials by Curing with two Colors of Light

Bialas, S.; Michalek, L.; Marschner, D. E.; Krappitz, T.; Wegener, M.; Blinco, J. P.; Blasco, E.; Frisch, H.; Barner-Kowollik, C. Adv. Mater. 2019, 31, 1807288.

[597] Tailoring the Mechanical Properties of 3D Microstructures Using Visible Light Post-Manufacturing

Gernhardt, M.; Blasco, E.; Hippler, M., Blinco, J. P.; Bastmeyer, M.; Wegener, M.; Frisch, H.; Barner-Kowollik, C. Adv. Mater. 2019, 31, 1901269.

[616] Hybrid Photo-induced Copolymerization of Ring-Strained and Vinyl Monomers Utilizing Metal-Free Ring-Opening Metathesis Polymerization Conditions

Krappitz, T.; Jovic, K.; Feist, F.; Frisch, H.; Rigoglioso, V. P.; Blinco, J. P.; Boydston, A. J.; Barner-Kowollik, C. J. Am. Chem. Soc. 2019, 141, 16605-16609.

[568] Making and Breaking Chemical Bonds by Chemiluminescence

Kockler, K. B.; Frisch, H.; Barner-Kowollik, C. Macromol. Rapid Commun. 2018, 39, 1800516. (see journal cover)

[558] Photochemistry in Confined Environments for Single-Chain Nanoparticle Design

Frisch, H:, Menzel, J. P.; Bloesser, F. R.; Marschner, D.; Mundsinger, K.; Barner-Kowollik, C. J. Am. Chem Soc. 2018, 140, 9551-9557. (see journal cover)

[537] Visible Light [2+2] Cycloadditions for Reversible Polymer Ligation

Marschner, D. E.; Frisch, H.; Offenloch, J. T.; Tuten, B. T.; Becer, R.; Walther, A.; Goldmann, A. S.; Tzvetkova, P.; Barner-Kowollik, C. Macromolecules 2018, 51, 3802-3807.

[527] Wavelength-Gated Dynamic Covalent Chemistry

Frisch, H.; Marschner, D.; Goldmann, A. S.; Barner-Kowollik, C. Angew. Chem. Int. Ed. 2018, 57, 2036-2045.

[39] Tuning the pH-Switch of Supramolecular Polymer Carriers for siRNA to Physiologically Relevant pH

Ahlers, P. ; Frisch, H.; Holm, R.; Spitzer, D.; Barz, M.; Besenius, P. Macromol. Biosci. 2017, 17, 1700111.

[514] Characterizing Single Chain Nanoparticles (SCNPs): A Critical Survey

Blasco, E.; Tuten, B. T.; Frisch, H.; Lederer, A.; Barner-Kowolik, C. Polym. Chem. 2017, 8, 5845-5851.

[41] Probing the Self-Assembly and Stability of Oligohistidine based Rod-like Micelles by Aggregation Induced Luminescence

Frisch, H.; Spitzer, D.; Haase, M.; Basché, T.; Voskuhl, J.; Besenius, P. Org. Biomol. Chem. 2016, 14, 5574-5579.

[40] Kinetically Controlled Sequential Growth of Surface-Grafted Chiral Supramolecular Copolymers

Frisch, H.; Fritz, E.-C.; Stricker, F.; Schmüser, L.; Spitzer, D.; Weidner, T.; Ravoo, B. J.; Besenius, P. Angew. Chem. Int. Ed. 2016, 55, 7242-7246.

[44] pH-Switchable Self-Assembled Materials

Frisch, H.; Besenius, P. Macromol. Rapid Commun. 2015, 36, 346-363.

[43] pH-Regulated Selectivity in Supramolecular Polymerizations: Switching Between Co- and Homopolymers

Frisch, H.; Nie, Y.; Raunser, S.; Besenius, P. Chem. Eur. J. 2015, 21, 3304-3309.

[42] Tuneable pH-Regulated Supramolecular Copolymerisation by Mixing Mismatched Dendritic Peptide Comonomers

Ahlers, P.; Frisch, H.; Besenius, P. Polym. Chem. 2015, 6, 7245-7250.

[46] Zwitterionic Phosphirenium Borates Derived from Bis(alkynyl)mesityl Phosphanes and Tris(pentafluorophenyl)borane

Möbus, J.; Malessa, K.; Frisch, H.; Daniliuc, C. G.; Fröhlich, R.; Kehr, G.; Erker, G. Heteroat. Chem. 2014, 25, 396-401.

[45] The Synthesis of Dendritic EDOT-Peptide Conjugates and Their Multistimuli-Responsive Self-Assembly Into Supramolecular Nanorods and Fibres in Water

Ahlers, P.; Frisch, H.; Spitzer, D.; Vobecka, Z.; Vilela, F.; Besenius, P.; Chem. Asian J. 2014, 9, 2052-2057.

[48] A Soft Supramolecular Carrier with Enhanced Singlet Oxygen Photosensitizing Properties

Voskuhl, J.; Kauscher, U.; Gruener, M.; Frisch, H.; Wibbeling, B.; Strassert, C. A.; Ravoo, B. J. Soft Matter 2013, 9, 2453-2457.

[47] pH-Switchable Ampholytic Supramolecular Copolymers

Frisch, H.; Unsleber, J. P.; Lüdeker, D.; Peterlechner, M.; Brunklaus, G.; Waller, M.; Besenius, P. Angew. Chem. Int. Ed. 2013, 52, 10097-10101.


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